SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM for Pim-1 compared to an IC50 of 100 nM for Pim-2 and with little or no activity against a panel of 50 other kinases tested
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化学信息
名称 | SMI-4a |
Iupac 化学名称 | (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione |
分子式 | C11H6F3NO2S |
分子量 | 273.23 |
Smile | O=C(NC/1=O)SC1=C/C2=CC=CC(C(F)(F)F)=C2 |
InChiKey | NGJLOFCOEOHFKQ-YVMONPNESA-N |
InChi | InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5- |
Cas号 | 438190-29-5 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder 6 months-80ºCin solvent |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature |
海关编码 | |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study | |