Serlopitant (VPD-737) is a drug which acts as an NK1 receptor antagonist. It was assessed in clinical trials for the treatment of urinary incontinence and overactive bladder, but while it was superior to placebo it provided no advantage over existing approved drugs, and was not approved for further development.
仅供研究使用。 我们不向患者出售。
名称 | Serlopitant(VPD-737) |
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Iupac 化学名称 | 3-((3aR,4R,5S,7aS)-5-((1R)-1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-4-(4 fluorophenyl)octahydro-2H-isoindol-2-yl)cyclopent-2-en-1-one |
同义词 | VPD-737; VPD737; VPD 737; MK-0594; MK 0594; MK0594 |
英文同义词 | VPD-737; VPD737; VPD 737; MK-0594; MK 0594; MK0594 |
分子式 | C29H28F7NO2 |
分子量 | 555.5368 |
Smile | FC(C=1C=C(C=C(C1)C(F)(F)F)[C@@H](C)O[C@@H]1[C@H]([C@@H]2CN(C[C@H]2CC1)C1=CC(CC1)=O)C1=CC=C(C=C1)F)(F)F |
InChiKey | FLNYCRJBCNNHRH-OIYLJQICSA-N |
InChi | InChI=1S/C29H28F7NO2/c1-16(19-10-20(28(31,32)33)12-21(11-19)29(34,35)36)39-26-9-4-18-14-37(23-7-8-24(38)13-23)15-25(18)27(26)17-2-5-22(30)6-3-17/h2-3,5-6,10-13,16,18,25-27H,4,7-9,14-15H2,1H3/t16-,18-,25-,26+,27+/m1/s1 |
Cas号 | 860642-69-9 |
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