Sobetirome
编号: 16070907
Cas号: 211110-63-3
纯度: 98% by HPLC
Sobetirome, also known as GC-1 and QRX-431, is a hyroid hormone beta-receptor agonist. Sobetirome inhibits proliferation but induces differentiation and TR beta mRNA expression in mouse and rat osteoblast-like cells. Sobetirome selectively binds to and activates TRbeta over TRalpha and this receptor selectivity led to the hypothesis that sobetirome would lower cholesterol through activation of liver TRbeta without stimulating cardiac function through TRalpha activation in the heart. The tissue selective thyromimetic properties of sobetirome have been demonstrated in numerous animal models, which led to its clinical development as a novel cholesterol-lowering agent.
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化学信息
| 名称 | Sobetirome |
|---|---|
| Iupac 化学名称 | 2-(4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid |
| 同义词 | GC-1; GC1; GC 1; QRX-431 |
| 英文同义词 | GC-1; GC1; GC 1; QRX-431 |
| 分子式 | C20H24O4 |
| 分子量 | 328.408 |
| Smile | OC1=C(C=C(CC2=C(C=C(OCC(=O)O)C=C2C)C)C=C1)C(C)C |
| InChiKey | QNAZTOHXCZPOSA-UHFFFAOYSA-N |
| InChi | InChI=1S/C20H24O4/c1-12(2)17-9-15(5-6-19(17)21)10-18-13(3)7-16(8-14(18)4)24-11-20(22)23/h5-9,12,21H,10-11H2,1-4H3,(H,22,23) |
| Cas号 | 211110-63-3 |
| 相关CAS号 |
订购信息
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