Sotrastaurin
编号: 16071004
Cas号: 425637-18-9
纯度: 98% by HPLC
Sotrastaurin, also known as AEB-071, is an orally available pan-protein kinase C (PKC) inhibitor with potential immunosuppressive and antineoplastic activities. Sotrastaurin inhibits both T- and B-cell activations via PKC theta and beta isozymes, respectively. Both PKCs are important in the activation of nuclear factor-kappaB (NF-kB). Inhibition of PKC beta in B-cells results in prevention of NF-kB-mediated signaling and down regulation of NF-kB target genes. This may eventually lead to an induction of G1 cell cycle arrest and tumor cell apoptosis in susceptible tumor cells. This agent may act synergistically with other chemotherapeutic agents.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Sotrastaurin |
|---|---|
| Iupac 化学名称 | 3-(1H-indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione |
| 同义词 | AEB071 |
| 英文同义词 | AEB071 |
| 分子式 | C25H22N6O2 |
| 分子量 | 438.48118 |
| Smile | N1C=C(C2=CC=CC=C12)C=1C(NC(C1C1=NC(=NC2=CC=CC=C12)N1CCN(CC1)C)=O)=O |
| InChiKey | OAVGBZOFDPFGPJ-UHFFFAOYSA-N |
| InChi | InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33) |
| Cas号 | 425637-18-9 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
