Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03M. In contrast, co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 M.
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化学信息
名称 | Spautin-1 |
同义词 | 6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amine |
英文同义词 | 6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amine |
分子式 | C15H11F2N3 |
分子量 | 271.26 |
Smile | C1=CC(=CC=C1CNC2=NC=NC3=C2C=C(C=C3)F)F |
InChiKey | AWIVHRPYFSSVOG-UHFFFAOYSA-N |
InChi | InChI=1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20) |
Cas号 | 1262888-28-7 |
相关CAS号 | |
外观性状 | Solid powder |
纯度 | 98% |
存储 | -20 ºC for 3 years |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |