TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC50 values of 20 and 15 nM, respectively, which exhibits considerably weaker inhibition of Clk2 and Clk3 (IC50 = 200 nM and >10 M, respectively).
仅供研究使用。 我们不向患者出售。
化学信息
名称 | TG003 |
Iupac 化学名称 | (1Z)-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one |
同义词 | TG 003; TG-003; Clk Inhibitor, TG003; Cdc2-Like Kinase Inhibitor |
英文同义词 | TG 003; TG-003; Clk Inhibitor, TG003; Cdc2-Like Kinase Inhibitor |
分子式 | C12H15NO2S |
分子量 | 237.318 |
Smile | CCN1C2=C(C=CC(=C2)OC)SC1=CC(=O)C |
InChiKey | BGVLELSCIHASRV-UHFFFAOYSA-N |
InChi | InChI=1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3 |
Cas号 | 300801-52-9 |
相关CAS号 | |
外观性状 | Solid powder |
纯度 | 98% |
存储 | -20 ºC for 3 years |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |