TG100-115, inhibited PI3K and -(IC50 values of 83 and 235 nM, respectively), whereas both PI3K and - were relatively unaffected (IC50 values>1 M). As a gauge of general specificity, TG100-115 was also assayed against a 133 protein kinase panel, none of which was inhibited at IC50 values<1 M.
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名称 | TG100-115 |
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Iupac 化学名称 | 3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol |
同义词 | TG100115; TG-100115; TG 100115; TG-100-115; TG100-115 ; TG 100-115. |
英文同义词 | TG100115; TG-100115; TG 100115; TG-100-115; TG100-115 ; TG 100-115. |
分子式 | C18H14N6O2 |
分子量 | 346.34276 |
Smile | NC1=NC2=NC(=C(N=C2C(=N1)N)C1=CC(=CC=C1)O)C=1C=C(C=CC1)O |
InChiKey | UJIAQDJKSXQLIT-UHFFFAOYSA-N |
InChi | InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24) |
Cas号 | 677297-51-7 |
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