1: Medipally A, Xiao M, Biederman L, Dasgupta A, Satoskar AA, Parikh S, Ivanov I, Mikhalina G, Brodsky SV. Role of plasminogen activated inhibitor-1 in the pathogenesis of anticoagulant related nephropathy. Front Nephrol. 2024 Jun 28;4:1406655. doi: 10.3389/fneph.2024.1406655. PMID: 39006160; PMCID: PMC11239567.
2: Cipolla MJ, Hunt RD, Liebeskind DS, Tremble SM. The impact of collateral therapeutics on stroke hemodynamics in normotensive and hypertensive rats: a step toward translation. Front Neurol. 2024 Mar 21;15:1373445. doi: 10.3389/fneur.2024.1373445. PMID: 38585360; PMCID: PMC10996366.
3: Tanaka K, Harada H, Kamuro H, Sakai H, Yamamoto A, Tomimatsu M, Ikeda A, Chosokabe R, Tanaka S, Okada Y, Fujio Y, Obana M. Arid5a/IL-6/PAI-1 Signaling Is Involved in the Pathogenesis of Lipopolysaccharide-Induced Kidney Injury. Biol Pharm Bull. 2023;46(12):1753-1760. doi: 10.1248/bpb.b23-00482. PMID: 38044094.
4: Palakurti R, Biswas N, Roy S, Gnyawali SC, Sinha M, Singh K, Ghatak S, Sen CK, Khanna S. Inducible miR-1224 silences cerebrovascular Serpine1 and restores blood flow to the stroke-affected site of the brain. Mol Ther Nucleic Acids. 2023 Jan 2;31:276-292. doi: 10.1016/j.omtn.2022.12.019. PMID: 36726407; PMCID: PMC9868883.
5: Shin E, Kang H, Lee H, Lee S, Jeon J, Seong K, Youn H, Youn B. Exosomal Plasminogen Activator Inhibitor-1 Induces Ionizing Radiation-Adaptive Glioblastoma Cachexia. Cells. 2022 Oct 1;11(19):3102. doi: 10.3390/cells11193102. PMID: 36231065; PMCID: PMC9564109.
6: Catarinella G, Nicoletti C, Bracaglia A, Procopio P, Salvatori I, Taggi M, Valle C, Ferri A, Canipari R, Puri PL, Latella L. SerpinE1 drives a cell- autonomous pathogenic signaling in Hutchinson-Gilford progeria syndrome. Cell Death Dis. 2022 Aug 26;13(8):737. doi: 10.1038/s41419-022-05168-y. PMID: 36028501; PMCID: PMC9418244.
7: Kuru Bektaşoğlu P, Koyuncuoğlu T, Akbulut S, Akakın D, Eyüboğlu İP, Erzik C, Yüksel M, Kurtel H. Neuroprotective Effect of Plasminogen Activator Inhibitor-1 Antagonist in the Rat Model of Mild Traumatic Brain Injury. Inflammation. 2021 Dec;44(6):2499-2517. doi: 10.1007/s10753-021-01520-0. Epub 2021 Aug 30. PMID: 34460025.
8: Levine JA, Olivares S, Miyata T, Vaughan DE, Henkel AS. Inhibition of PAI-1 Promotes Lipolysis and Enhances Weight Loss in Obese Mice. Obesity (Silver Spring). 2021 Apr;29(4):713-720. doi: 10.1002/oby.23112. Epub 2021 Feb 16. PMID: 33594826; PMCID: PMC8842994.
9: Sillen M, Miyata T, Vaughan DE, Strelkov SV, Declerck PJ. Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484. Int J Mol Sci. 2021 Feb 2;22(3):1482. doi: 10.3390/ijms22031482. PMID: 33540702; PMCID: PMC7867230.
10: Hosaka S, Yamada T, Takahashi K, Dan T, Kaneko K, Kodama S, Asai Y, Munakata Y, Endo A, Sugawara H, Kawana Y, Yamamoto J, Izumi T, Sawada S, Imai J, Miyata T, Katagiri H. Inhibition of Plasminogen Activator Inhibitor-1 Activation Suppresses High Fat Diet-Induced Weight Gain via Alleviation of Hypothalamic Leptin Resistance. Front Pharmacol. 2020 Jun 24;11:943. doi: 10.3389/fphar.2020.00943. PMID: 32670063; PMCID: PMC7327106.
11: Garcia V, Park EJ, Siragusa M, Frohlich F, Mahfuzul Haque M, Pascale JV, Heberlein KR, Isakson BE, Stuehr DJ, Sessa WC. Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9497-9507. doi: 10.1073/pnas.1918761117. Epub 2020 Apr 16. PMID: 32300005; PMCID: PMC7196906.
12: Lang SQ, Lang WH, Yu HY, Wang L. Metabolic activation of TM5441 in vitro and in vivo: Formation of reactive metabolites and human enzymes involved. Eur J Pharm Sci. 2020 Feb 15;143:105195. doi: 10.1016/j.ejps.2019.105195. Epub 2019 Dec 15. PMID: 31852629.
13: Sun T, Ghosh AK, Eren M, Miyata T, Vaughan DE. PAI-1 contributes to homocysteine-induced cellular senescence. Cell Signal. 2019 Dec;64:109394. doi: 10.1016/j.cellsig.2019.109394. Epub 2019 Aug 28. PMID: 31472244; PMCID: PMC6936332.
14: Miller RA, Harrison DE, Astle CM, Bogue MA, Brind J, Fernandez E, Flurkey K, Javors M, Ladiges W, Leeuwenburgh C, Macchiarini F, Nelson J, Ryazanov AG, Snyder J, Stearns TM, Vaughan DE, Strong R. Glycine supplementation extends lifespan of male and female mice. Aging Cell. 2019 Jun;18(3):e12953. doi: 10.1111/acel.12953. Epub 2019 Mar 27. PMID: 30916479; PMCID: PMC6516426.
15: Henkel AS, Khan SS, Olivares S, Miyata T, Vaughan DE. Inhibition of Plasminogen Activator Inhibitor 1 Attenuates Hepatic Steatosis but Does Not Prevent Progressive Nonalcoholic Steatohepatitis in Mice. Hepatol Commun. 2018 Sep 26;2(12):1479-1492. doi: 10.1002/hep4.1259. PMID: 30556037; PMCID: PMC6287480.
16: Chan SL, Bishop N, Li Z, Cipolla MJ. Inhibition of PAI (Plasminogen Activator Inhibitor)-1 Improves Brain Collateral Perfusion and Injury After Acute Ischemic Stroke in Aged Hypertensive Rats. Stroke. 2018 Aug;49(8):1969-1976. doi: 10.1161/STROKEAHA.118.022056. PMID: 29991657; PMCID: PMC6202199.
17: Lee SM, Dorotea D, Jung I, Nakabayashi T, Miyata T, Ha H. TM5441, a plasminogen activator inhibitor-1 inhibitor, protects against high fat diet- induced non-alcoholic fatty liver disease. Oncotarget. 2017 Sep 21;8(52):89746-89760. doi: 10.18632/oncotarget.21120. PMID: 29163785; PMCID: PMC5685706.
18: Eren M, Place AT, Thomas PM, Flevaris P, Miyata T, Vaughan DE. PAI-1 is a critical regulator of FGF23 homeostasis. Sci Adv. 2017 Sep 13;3(9):e1603259. doi: 10.1126/sciadv.1603259. PMID: 28924605; PMCID: PMC5597312.
19: Ghosh AK, Rai R, Park KE, Eren M, Miyata T, Wilsbacher LD, Vaughan DE. A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence. Oncotarget. 2016 Nov 8;7(45):72443-72457. doi: 10.18632/oncotarget.12494. PMID: 27736799; PMCID: PMC5341920.
20: Piao L, Jung I, Huh JY, Miyata T, Ha H. A novel plasminogen activator inhibitor-1 inhibitor, TM5441, protects against high-fat diet-induced obesity and adipocyte injury in mice. Br J Pharmacol. 2016 Sep;173(17):2622-32. doi: 10.1111/bph.13541. Epub 2016 Jul 28. PMID: 27339909; PMCID: PMC4978161.