武汉永璨生物科技有限公司
+86-17702719238 sales@sun-shinechem.com

TM5441sodium

编号: 24149
Cas号: 2319722-53-5
纯度: 98% Min.

TM-5441, also known as EBP 883 and BMS-790052, is a potent plasminogen activator inhibitor-1 (PAI-1). TM-5441 inhibits several tumor cell lines with IC50 values between 9.7 and 60.3 μM. TM5441 protects against high-fat diet-induced obesity and adipocyte injury in mice.

仅供研究使用。 我们不向患者出售。

化学信息

名称TM5441sodium
Iupac 化学名称5-Chloro-2-[[2-[2-[[3-(3-furanyl)phenyl]amino]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt
同义词TM5441sodiumTM-5441; TM 5441; TM5441; BMS-790052; BMS-790052; BMS790052; EBP 883; EBP-883; EBP883.
英文同义词TM5441sodiumTM-5441; TM 5441; TM5441; BMS-790052; BMS-790052; BMS790052; EBP 883; EBP-883; EBP883.
分子式C21H16ClN2NaO6
分子量450.80
SmileO=C([O-])C1=CC(Cl)=CC=C1NC(COCC(NC2=CC=CC(C3=COC=C3)=C2)=O)=O.[Na+]
InChiKeyRDKPAESSEMYFJL-UHFFFAOYSA-M
InChiInChI=1S/C21H17ClN2O6.Na/c22-15-4-5-18(17(9-15)21(27)28)24-20(26)12-30-11-19(25)23-16-3-1-2-13(8-16)14-6-7-29-10-14;/h1-10H,11-12H2,(H,23,25)(H,24,26)(H,27,28);/q;+1/p-1
Cas号2319722-53-5
相关CAS号

订购信息

包装价格库存纯度备货期
大货询价询价询价
Request Bulk Quote Download MSDS 电话 : +86-177 0271 9238   Email : sales@sun-shinechem.com
外观性状类白色固体
纯度98% Min.
存储 0-4℃,可保存几天到几周;-20℃,可保存 几个月。
可溶性溶于DMSO等有机溶剂
处理方式
运输条件可以在室温下进行运输。
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Medipally A, Xiao M, Biederman L, Dasgupta A, Satoskar AA, Parikh S, Ivanov I, Mikhalina G, Brodsky SV. Role of plasminogen activated inhibitor-1 in the pathogenesis of anticoagulant related nephropathy. Front Nephrol. 2024 Jun 28;4:1406655. doi: 10.3389/fneph.2024.1406655. PMID: 39006160; PMCID: PMC11239567.


2: Cipolla MJ, Hunt RD, Liebeskind DS, Tremble SM. The impact of collateral therapeutics on stroke hemodynamics in normotensive and hypertensive rats: a step toward translation. Front Neurol. 2024 Mar 21;15:1373445. doi: 10.3389/fneur.2024.1373445. PMID: 38585360; PMCID: PMC10996366.


3: Tanaka K, Harada H, Kamuro H, Sakai H, Yamamoto A, Tomimatsu M, Ikeda A, Chosokabe R, Tanaka S, Okada Y, Fujio Y, Obana M. Arid5a/IL-6/PAI-1 Signaling Is Involved in the Pathogenesis of Lipopolysaccharide-Induced Kidney Injury. Biol Pharm Bull. 2023;46(12):1753-1760. doi: 10.1248/bpb.b23-00482. PMID: 38044094.


4: Palakurti R, Biswas N, Roy S, Gnyawali SC, Sinha M, Singh K, Ghatak S, Sen CK, Khanna S. Inducible miR-1224 silences cerebrovascular Serpine1 and restores blood flow to the stroke-affected site of the brain. Mol Ther Nucleic Acids. 2023 Jan 2;31:276-292. doi: 10.1016/j.omtn.2022.12.019. PMID: 36726407; PMCID: PMC9868883.


5: Shin E, Kang H, Lee H, Lee S, Jeon J, Seong K, Youn H, Youn B. Exosomal Plasminogen Activator Inhibitor-1 Induces Ionizing Radiation-Adaptive Glioblastoma Cachexia. Cells. 2022 Oct 1;11(19):3102. doi: 10.3390/cells11193102. PMID: 36231065; PMCID: PMC9564109.


6: Catarinella G, Nicoletti C, Bracaglia A, Procopio P, Salvatori I, Taggi M, Valle C, Ferri A, Canipari R, Puri PL, Latella L. SerpinE1 drives a cell- autonomous pathogenic signaling in Hutchinson-Gilford progeria syndrome. Cell Death Dis. 2022 Aug 26;13(8):737. doi: 10.1038/s41419-022-05168-y. PMID: 36028501; PMCID: PMC9418244.


7: Kuru Bektaşoğlu P, Koyuncuoğlu T, Akbulut S, Akakın D, Eyüboğlu İP, Erzik C, Yüksel M, Kurtel H. Neuroprotective Effect of Plasminogen Activator Inhibitor-1 Antagonist in the Rat Model of Mild Traumatic Brain Injury. Inflammation. 2021 Dec;44(6):2499-2517. doi: 10.1007/s10753-021-01520-0. Epub 2021 Aug 30. PMID: 34460025.


8: Levine JA, Olivares S, Miyata T, Vaughan DE, Henkel AS. Inhibition of PAI-1 Promotes Lipolysis and Enhances Weight Loss in Obese Mice. Obesity (Silver Spring). 2021 Apr;29(4):713-720. doi: 10.1002/oby.23112. Epub 2021 Feb 16. PMID: 33594826; PMCID: PMC8842994.


9: Sillen M, Miyata T, Vaughan DE, Strelkov SV, Declerck PJ. Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484. Int J Mol Sci. 2021 Feb 2;22(3):1482. doi: 10.3390/ijms22031482. PMID: 33540702; PMCID: PMC7867230.


10: Hosaka S, Yamada T, Takahashi K, Dan T, Kaneko K, Kodama S, Asai Y, Munakata Y, Endo A, Sugawara H, Kawana Y, Yamamoto J, Izumi T, Sawada S, Imai J, Miyata T, Katagiri H. Inhibition of Plasminogen Activator Inhibitor-1 Activation Suppresses High Fat Diet-Induced Weight Gain via Alleviation of Hypothalamic Leptin Resistance. Front Pharmacol. 2020 Jun 24;11:943. doi: 10.3389/fphar.2020.00943. PMID: 32670063; PMCID: PMC7327106.


11: Garcia V, Park EJ, Siragusa M, Frohlich F, Mahfuzul Haque M, Pascale JV, Heberlein KR, Isakson BE, Stuehr DJ, Sessa WC. Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9497-9507. doi: 10.1073/pnas.1918761117. Epub 2020 Apr 16. PMID: 32300005; PMCID: PMC7196906.


12: Lang SQ, Lang WH, Yu HY, Wang L. Metabolic activation of TM5441 in vitro and in vivo: Formation of reactive metabolites and human enzymes involved. Eur J Pharm Sci. 2020 Feb 15;143:105195. doi: 10.1016/j.ejps.2019.105195. Epub 2019 Dec 15. PMID: 31852629.


13: Sun T, Ghosh AK, Eren M, Miyata T, Vaughan DE. PAI-1 contributes to homocysteine-induced cellular senescence. Cell Signal. 2019 Dec;64:109394. doi: 10.1016/j.cellsig.2019.109394. Epub 2019 Aug 28. PMID: 31472244; PMCID: PMC6936332.


14: Miller RA, Harrison DE, Astle CM, Bogue MA, Brind J, Fernandez E, Flurkey K, Javors M, Ladiges W, Leeuwenburgh C, Macchiarini F, Nelson J, Ryazanov AG, Snyder J, Stearns TM, Vaughan DE, Strong R. Glycine supplementation extends lifespan of male and female mice. Aging Cell. 2019 Jun;18(3):e12953. doi: 10.1111/acel.12953. Epub 2019 Mar 27. PMID: 30916479; PMCID: PMC6516426.


15: Henkel AS, Khan SS, Olivares S, Miyata T, Vaughan DE. Inhibition of Plasminogen Activator Inhibitor 1 Attenuates Hepatic Steatosis but Does Not Prevent Progressive Nonalcoholic Steatohepatitis in Mice. Hepatol Commun. 2018 Sep 26;2(12):1479-1492. doi: 10.1002/hep4.1259. PMID: 30556037; PMCID: PMC6287480.


16: Chan SL, Bishop N, Li Z, Cipolla MJ. Inhibition of PAI (Plasminogen Activator Inhibitor)-1 Improves Brain Collateral Perfusion and Injury After Acute Ischemic Stroke in Aged Hypertensive Rats. Stroke. 2018 Aug;49(8):1969-1976. doi: 10.1161/STROKEAHA.118.022056. PMID: 29991657; PMCID: PMC6202199.


17: Lee SM, Dorotea D, Jung I, Nakabayashi T, Miyata T, Ha H. TM5441, a plasminogen activator inhibitor-1 inhibitor, protects against high fat diet- induced non-alcoholic fatty liver disease. Oncotarget. 2017 Sep 21;8(52):89746-89760. doi: 10.18632/oncotarget.21120. PMID: 29163785; PMCID: PMC5685706.


18: Eren M, Place AT, Thomas PM, Flevaris P, Miyata T, Vaughan DE. PAI-1 is a critical regulator of FGF23 homeostasis. Sci Adv. 2017 Sep 13;3(9):e1603259. doi: 10.1126/sciadv.1603259. PMID: 28924605; PMCID: PMC5597312.


19: Ghosh AK, Rai R, Park KE, Eren M, Miyata T, Wilsbacher LD, Vaughan DE. A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence. Oncotarget. 2016 Nov 8;7(45):72443-72457. doi: 10.18632/oncotarget.12494. PMID: 27736799; PMCID: PMC5341920.


20: Piao L, Jung I, Huh JY, Miyata T, Ha H. A novel plasminogen activator inhibitor-1 inhibitor, TM5441, protects against high-fat diet-induced obesity and adipocyte injury in mice. Br J Pharmacol. 2016 Sep;173(17):2622-32. doi: 10.1111/bph.13541. Epub 2016 Jul 28. PMID: 27339909; PMCID: PMC4978161.

化学结构

24149 - TM5441sodium | CAS 2319722-53-5

快速订购

Change