Targocil
Targocil is a antibiotic, inhibiting a late step in wall teichoic acid biosynthesis and inducing the cell wall stress stimulon in staphylococcus aureus.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Targocil |
|---|---|
| Iupac 化学名称 | 3-(4-Chlorophenylsulfonyl)-N,N-diethyl-7,8-dimethoxy-[1,2,3]triazolo[1,5-a]quinazolin-5-amine |
| 同义词 | QC-993; QC 993; QC993; Targocil; |
| 英文同义词 | QC-993; QC 993; QC993; Targocil; |
| 分子式 | C21H22ClN5O4S |
| 分子量 | 475.948 |
| Smile | COC1=CC2=C(C=C1OC)C(N(CC)CC)=NC3=C(S(=O)(C4=CC=C(Cl)C=C4)=O)N=NN32 |
| InChiKey | TYNZGYMGTTUYKZ-UHFFFAOYSA-N |
| InChi | InChI=1S/C21H22ClN5O4S/c1-5-26(6-2)19-15-11-17(30-3)18(31-4)12-16(15)27-20(23-19)21(24-25-27)32(28,29)14-9-7-13(22)8-10-14/h7-12H,5-6H2,1-4H3 |
| Cas号 | 1200443-21-5 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 可溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周 |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Tiwari KB, Gatto C, Walker S, Wilkinson BJ. Exposure of Staphylococcus aureus to Targocil Blocks Translocation of the Major Autolysin Atl across the Membrane, Resulting in a Significant Decrease in Autolysis. Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00323-18. doi: 10.1128/AAC.00323-18. Print 2018 Jul. PubMed PMID: 29735561; PubMed Central PMCID: PMC6021642.
2: Klahn P, Brönstrup M. New Structural Templates for Clinically Validated and Novel Targets in Antimicrobial Drug Research and Development. Curr Top Microbiol Immunol. 2016;398:365-417. doi: 10.1007/82_2016_501. Review. PubMed PMID: 27704270.
3: Czarny TL, Brown ED. A Small-Molecule Screening Platform for the Discovery of Inhibitors of Undecaprenyl Diphosphate Synthase. ACS Infect Dis. 2016 Jul 8;2(7):489-99. doi: 10.1021/acsinfecdis.6b00044. Epub 2016 May 24. PubMed PMID: 27626101.
4: Farha MA, Czarny TL, Myers CL, Worrall LJ, French S, Conrady DG, Wang Y, Oldfield E, Strynadka NC, Brown ED. Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11048-53. doi: 10.1073/pnas.1511751112. Epub 2015 Aug 17. PubMed PMID: 26283394; PubMed Central PMCID: PMC4568241.
5: Campbell J, Singh AK, Swoboda JG, Gilmore MS, Wilkinson BJ, Walker S. An antibiotic that inhibits a late step in wall teichoic acid biosynthesis induces the cell wall stress stimulon in Staphylococcus aureus. Antimicrob Agents Chemother. 2012 Apr;56(4):1810-20. doi: 10.1128/AAC.05938-11. Epub 2012 Jan 30. PubMed PMID: 22290958; PubMed Central PMCID: PMC3318382.
6: Suzuki T. A new target for Staphylococcus aureus associated with keratitis. Cornea. 2011 Oct;30 Suppl 1:S34-40. doi: 10.1097/ICO.0b013e3182282100. Review. PubMed PMID: 21912228.
7: Schirner K, Stone LK, Walker S. ABC transporters required for export of wall teichoic acids do not discriminate between different main chain polymers. ACS Chem Biol. 2011 May 20;6(5):407-12. doi: 10.1021/cb100390w. Epub 2011 Feb 15. PubMed PMID: 21280653; PubMed Central PMCID: PMC3098905.
8: Suzuki T, Swoboda JG, Campbell J, Walker S, Gilmore MS. In vitro antimicrobial activity of wall teichoic acid biosynthesis inhibitors against Staphylococcus aureus isolates. Antimicrob Agents Chemother. 2011 Feb;55(2):767-74. doi: 10.1128/AAC.00879-10. Epub 2010 Nov 22. PubMed PMID: 21098254; PubMed Central PMCID: PMC3028815.
9: Lee K, Campbell J, Swoboda JG, Cuny GD, Walker S. Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1767-70. doi: 10.1016/j.bmcl.2010.01.036. Epub 2010 Jan 20. PubMed PMID: 20138521; PubMed Central PMCID: PMC2844852.
