Timapiprant, also known as OC000459, is a potent, selective and orally active CRTH2 antagonist. OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial.
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名称 | Timapiprant |
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Iupac 化学名称 | 2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-indol-1-yl)acetic acid |
同义词 | OC000459; OC-000459; OC 000459; Timapiprant. |
英文同义词 | OC000459; OC-000459; OC 000459; Timapiprant. |
分子式 | C21H17FN2O2 |
分子量 | 348.3774 |
Smile | O=C(O)CN1C(C)=C(CC2=NC3=CC=CC=C3C=C2)C4=C1C=CC(F)=C4 |
InChiKey | FATGTHLOZSXOBC-UHFFFAOYSA-N |
InChi | InChI=1S/C21H17FN2O2/c1-13-17(11-16-8-6-14-4-2-3-5-19(14)23-16)18-10-15(22)7-9-20(18)24(13)12-21(25)26/h2-10H,11-12H2,1H3,(H,25,26) |
Cas号 | 851723-84-7 |
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