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Tomivosertib HCl

编号: 20673
Cas号: 1849590-02-8
纯度: 98% Min.

Tomivosertib, also known as eFT508 is a MNK1/2 inhibitor. Tomivosertib binds to and inhibits the activity of MNK1 and 2. This prevents MNK1/2-mediated signaling, and inhibits the phosphorylation of certain regulatory proteins, including eukaryotic translation initiation factor 4E (eIF4E), that regulate the translation of messenger RNAs (mRNAs) involved in tumor cell proliferation, angiogenesis, survival and immune signaling.

仅供研究使用。 我们不向患者出售。

化学信息

名称Tomivosertib HCl
Iupac 化学名称6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione hydrochloride
同义词Tomivosertib HCl; hydrochloride; Tomivosertib HCl; eFT508; eFT-508; eFT 508; eFT508 hydrochloride
英文同义词Tomivosertib HCl; hydrochloride; Tomivosertib HCl; eFT508; eFT-508; eFT 508; eFT508 hydrochloride
分子式C17H21ClN6O2
分子量376.84
SmileO=C(C1=C(C)C=C(NC2=NC=NC(N)=C2)C(N13)=O)NC43CCCCC4.[H]Cl
InChiKeyWBGPPUUXCGKTSC-UHFFFAOYSA-N
InChiInChI=1S/C17H20N6O2.ClH/c1-10-7-11(21-13-8-12(18)19-9-20-13)16(25)23-14(10)15(24)22-17(23)5-3-2-4-6-17;/h7-9H,2-6H2,1H3,(H,22,24)(H3,18,19,20,21);1H
Cas号1849590-02-8
相关CAS号

订购信息

包装价格库存纯度备货期
大货询价询价询价
Request Bulk Quote Download MSDS 电话 : +86-177 0271 9238   Email : sales@sun-shinechem.com
外观性状类白色固体
纯度98% Min.
存储 0-4℃,可保存几天到几周;-20℃,可保存 几个月。
可溶性溶于DMSO等有机溶剂
处理方式Refer to MSDS
运输条件可以在室温下进行运输。
海关编码2934200090
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Megat S, Ray PR, Moy JK, Lou TF, Barragan-Iglesias P, Li Y, Pradhan G,
Wanghzou A, Ahmad A, Burton MD, North RY, Dougherty PM, Khoutorsky A, Sonenberg
N, Webster KR, Dussor G, Campbell ZT, Price TJ. Nociceptor translational
profiling reveals the Ragulator-Rag GTPase complex as a critical generator of
neuropathic pain. J Neurosci. 2018 Nov 20. pii: 2661-18. doi:
10.1523/JNEUROSCI.2661-18.2018. [Epub ahead of print] PubMed PMID: 30459229.


2: Reich SH, Sprengeler PA, Chiang GG, Appleman JR, Chen J, Clarine J, Eam B,
Ernst JT, Han Q, Goel VK, Han EZR, Huang V, Hung INJ, Jemison A, Jessen KA,
Molter J, Murphy D, Neal M, Parker GS, Shaghafi M, Sperry S, Staunton J, Stumpf
CR, Thompson PA, Tran C, Webber SE, Wegerski CJ, Zheng H, Webster KR.
Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated
Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1
and 2 (MNK1/2) Inhibition. J Med Chem. 2018 Apr 26;61(8):3516-3540. doi:
10.1021/acs.jmedchem.7b01795. Epub 2018 Mar 29. PubMed PMID: 29526098.


3: Dreas A, Mikulski M, Milik M, Fabritius CH, Brzózka K, Rzymski T.
Mitogen-activated Protein Kinase (MAPK) Interacting Kinases 1 and 2 (MNK1 and
MNK2) as Targets for Cancer Therapy: Recent Progress in the Development of MNK
Inhibitors. Curr Med Chem. 2017;24(28):3025-3053. doi:
10.2174/0929867324666170203123427. Review. PubMed PMID: 28164761.

化学结构

20673 - Tomivosertib HCl | CAS 1849590-02-8

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