Tuvusertib
编号: 24069
Cas号: 1613200-51-3
纯度: 98% Min.
Tuvusertib, also known as M-1774 and ATR inhibitor 1, is a ATR inhibitor. M1774 selectively inhibits ATR activity and blocks the downstream phosphorylation of the serine/threonine protein kinase checkpoint kinase 1 (CHK1). This prevents ATR-mediated signaling, which results in the inhibition of DNA damage checkpoint activation, the disruption of DNA damage repair, and the induction of tumor cell apoptosis.
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化学信息
| 名称 | Tuvusertib |
|---|---|
| Iupac 化学名称 | 2-amino-6-fluoro-N-(5-fluoro-4-(1-methyl-1H-imidazol-5-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide |
| 同义词 | M-1774; M 1774; M1774; Tuvusertib; |
| 英文同义词 | M-1774; M 1774; M1774; Tuvusertib; |
| 分子式 | C16H12F2N8O |
| 分子量 | 370.32 |
| Smile | O=C(C1=C2N=CC(F)=CN2N=C1N)NC3=C(C4=CN=CN4C)C(F)=CN=C3 |
| InChiKey | RBQPCTBFIPVIJN-UHFFFAOYSA-N |
| InChi | InChI=1S/C16H12F2N8O/c1-25-7-21-5-11(25)12-9(18)3-20-4-10(12)23-16(27)13-14(19)24-26-6-8(17)2-22-15(13)26/h2-7H,1H3,(H2,19,24)(H,23,27) |
| Cas号 | 1613200-51-3 |
| 相关CAS号 |
订购信息
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