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VK-28

编号: 24154
Cas号: 312611-92-0
纯度: 98% Min.

VK-28, a brain-permeable iron chelator, inhibits both basal and Fe/ascorbate-induced mitochondrial membrane lipid peroxidation.

仅供研究使用。 我们不向患者出售。

化学信息

名称VK-28
Iupac 化学名称5-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)quinolin-8-ol
同义词VK-28; VK 28; VK28
英文同义词VK-28; VK 28; VK28
分子式C16H21N3O2
分子量287.36
SmileOCCN1CCN(CC1)CC2=C3C=CC=NC3=C(C=C2)O
InChiKeyXIXFNVDWEWCEOI-UHFFFAOYSA-N
InChiInChI=1S/C16H21N3O2/c20-11-10-18-6-8-19(9-7-18)12-13-3-4-15(21)16-14(13)2-1-5-17-16/h1-5,20-21H,6-12H2
Cas号312611-92-0
相关CAS号

订购信息

包装价格库存纯度备货期
大货询价询价询价
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外观性状类白色固体
纯度98% Min.
存储 0-4℃,可保存几天到几周;-20℃,可保存 几个月。
可溶性溶于DMSO等有机溶剂
处理方式
运输条件可以在室温下进行运输。
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Li Q, Wan J, Lan X, Han X, Wang Z, Wang J. Neuroprotection of brain-permeable
iron chelator VK-28 against intracerebral hemorrhage in mice. J Cereb Blood Flow
Metab. 2017 Sep;37(9):3110-3123. doi: 10.1177/0271678X17709186. Epub 2017 May
23. PMID: 28534662; PMCID: PMC5584702.

2: Shachar DB, Kahana N, Kampel V, Warshawsky A, Youdim MB. Neuroprotection by a
novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in
rats. Neuropharmacology. 2004 Feb;46(2):254-63. doi:
10.1016/j.neuropharm.2003.09.005. PMID: 14680763.

3: Youdim MB, Fridkin M, Zheng H. Bifunctional drug derivatives of MAO-B
inhibitor rasagiline and iron chelator VK-28 as a more effective approach to
treatment of brain ageing and ageing neurodegenerative diseases. Mech Ageing
Dev. 2005 Feb;126(2):317-26. doi: 10.1016/j.mad.2004.08.023. PMID: 15621213.

4: Bandyopadhyay S, Huang X, Cho H, Greig NH, Youdim MB, Rogers JT. Metal
specificity of an iron-responsive element in Alzheimer's APP mRNA 5'untranslated
region, tolerance of SH-SY5Y and H4 neural cells to desferrioxamine, clioquinol,
VK-28, and a piperazine chelator. J Neural Transm Suppl. 2006;(71):237-47. doi:
10.1007/978-3-211-33328-0_25. PMID: 17447434.

5: Youdim MB, Stephenson G, Ben Shachar D. Ironing iron out in Parkinson's
disease and other neurodegenerative diseases with iron chelators: a lesson from
6-hydroxydopamine and iron chelators, desferal and VK-28. Ann N Y Acad Sci. 2004
Mar;1012:306-25. doi: 10.1196/annals.1306.025. PMID: 15105275.

化学结构

24154 - VK-28 | CAS 312611-92-0

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