VX-702, one of a series of second-generation, is an orally active p38 MAP kinase inhibitors, for the potential treatment of inflammation, rheumatoid arthritis and cardiovascular diseases. VX-702 prevents activation of p38MAPK and decrements in many platelet storage parameters after exposure to 16 C without agitation for 24 h.
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化学信息
名称 | VX-702 |
Iupac 化学名称 | 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide |
同义词 | VX702; VX 702 |
英文同义词 | VX702; VX 702 |
分子式 | C19H12F4N4O2 |
分子量 | 404.31779 |
Smile | NC(=O)N(C1=CC=C(C(=N1)C1=C(C=C(C=C1)F)F)C(=O)N)C1=C(C=CC=C1F)F |
InChiKey | FYSRKRZDBHOFAY-UHFFFAOYSA-N |
InChi | InChI=1S/C19H12F4N4O2/c20-9-4-5-10(14(23)8-9)16-11(18(24)28)6-7-15(26-16)27(19(25)29)17-12(21)2-1-3-13(17)22/h1-8H,(H2,24,28)(H2,25,29) |
Cas号 | 745833-23-2 |
相关CAS号 | |
外观性状 | Solid powder |
纯度 | 98% by HPLC |
存储 | -20 ºC for 3 years |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |