XPW1
编号: 20659
Cas号: 2700286-66-2
纯度: 98% Min.
XPW1 is a potent and selective CDK9 inhibitor with excellent activity against clear cell renal cell carcinoma (ccRCC) and low toxicity.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | XPW1 |
|---|---|
| Iupac 化学名称 | N-((1r,4r)-4-((5'-chloro-6-((3-fluorobenzyl)amino)-[2,4'-bipyridin]-2'-yl)amino)cyclohexyl)-4-((E)-4-(dimethylamino)but-2-enamido)benzamide |
| 同义词 | XPW1; XPW-1; XPW 1 |
| 英文同义词 | XPW1; XPW-1; XPW 1 |
| 分子式 | C36H39ClFN7O2 |
| 分子量 | 656.19 |
| Smile | O=C(N[C@H]1CC[C@H](NC2=NC=C(Cl)C(C3=NC(NCC4=CC=CC(F)=C4)=CC=C3)=C2)CC1)C5=CC=C(NC(/C=C/CN(C)C)=O)C=C5 |
| InChiKey | DCNDHFXVQIDEQS-QYBHMFEJSA-N |
| InChi | InChI=1S/C36H39ClFN7O2/c1-45(2)19-5-10-35(46)42-28-13-11-25(12-14-28)36(47)43-29-17-15-27(16-18-29)41-34-21-30(31(37)23-40-34)32-8-4-9-33(44-32)39-22-24-6-3-7-26(38)20-24/h3-14,20-21,23,27,29H,15-19,22H2,1-2H3,(H,39,44)(H,40,41)(H,42,46)(H,43,47)/b10-5+/t27-,29- |
| Cas号 | 2700286-66-2 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | Solid powder |
|---|---|
| 纯度 | 98% Min. |
| 存储 | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| 可溶性 | Soluble in DMSO |
| 处理方式 | |
| 运输条件 | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| 海关编码 |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Kuang Z, Guo K, Cao Y, Jiang M, Wang C, Wu Q, Hu G, Ao M, Huang M, Qin J, Zhao T, Lu S, Sun C, Li M, Wu T, Liu W, Fang M. The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma. Br J Cancer. 2023 Oct 26. doi: 10.1038/s41416-023-02464-y. Epub ahead of print. PMID: 37884683.
