Xanomeline tartrate
Xanomeline (LY-246,708) 是一种正构毒蕈碱乙酰胆碱受体 (mAChR) 激动剂，通常被称为 M1/M4-preferring。它也被称为 M5 受体拮抗剂。 Xanomeline 在精神分裂症的临床试验 I 期进行了研究。在阿尔茨海默病患者的 II 期临床试验中，xanomeline 显着改善了认知功能的多项指标，但产生了患者依赖性的不良副作用。副作用似乎与口服给药后烷氧基侧链的快速代谢有关，导致一种非选择性但具有有限治疗效用的活性化合物。
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Xanomeline tartrate |
|---|---|
| Iupac 化学名称 | Pyridine, 3-(4-(hexyloxy)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methyl-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1) |
| 同义词 | LY246708 ; LY 246708 ; LY-246708 ; Xanomeline tartrate |
| 英文同义词 | LY246708 ; LY 246708 ; LY-246708 ; Xanomeline tartrate |
| 分子式 | C18H29N3O7S |
| 分子量 | 431.50 |
| Smile | CN1CCC=C(C2=NSN=C2OCCCCCC)C1.O=C(O)[C@H](O)[C@@H](O)C(O)=O |
| InChiKey | SJSVWTMVMBGIHQ-LREBCSMRSA-N |
| InChi | InChI=1S/C14H23N3OS.C4H6O6/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12;5-1(3(7)8)2(6)4(9)10/h8H,3-7,9-11H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1 |
| Cas号 | 152854-19-8 (tartrate) |
| 相关CAS号 | 131986-45-3 (free base) 141064-23-5 (oxalate) 152854-19-8 (tartrate) |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | ≧98.0% |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 溶于DMSO |
| 处理方式 | Refer to MSDS operation |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周. |
| 海关编码 | 2934200090 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
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