Y27632 is a selective ROCK inhibitor, which inhibits ET-1-induced increases in natriuretic peptide production, cell size, protein synthesis, and myofibrillar organization. Y27632 prevents dimethylnitrosamine-induced hepatic fibrosis in rats, increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium, affects initial heart myofibrillogenesis in cultured chick blastoderm, promotes the proliferation and cell cycle progression of cultured astrocyte from spinal cord.
仅供研究使用。 我们不向患者出售。
化学信息
名称 | Y27632(free base) |
Iupac 化学名称 | (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide |
同义词 | Y27632; Y-27632 |
英文同义词 | Y27632; Y-27632 |
分子式 | C14H21N3O |
分子量 | 247.34 |
Smile | C[C@H]([C@H]1CC[C@@H](CC1)C(=O)Nc2ccncc2)N |
InChiKey | IYOZTVGMEWJPKR-IJLUTSLNSA-N |
InChi | InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1 |
Cas号 | 146986-50-7 |
MDL | MFCD03093855 |
相关CAS号 | |
外观性状 | Solid powder |
纯度 | 98% by HPLC |
存储 | -20 ºC for 3 years |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |