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YW2065

编号: 20494
Cas号: 2131223-85-1
纯度: 98% Min.

YW2065 has excellent anti-colorectal cancer effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity.

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化学信息

名称YW2065
Iupac 化学名称1H-​Pyrazole-​4-​carboxamide, 1-​(2-​bromophenyl)​-​5-​methyl-​N-​2-​quinolinyl-
同义词YW2065; YW 2065; YW-2065;
英文同义词YW2065; YW 2065; YW-2065;
分子式C20H15BrN4O
分子量407.26
SmileBrC(C=CC=C1)=C1N2N=CC(C(NC(C=C3)=NC4=C3C=CC=C4)=O)=C2C
InChiKeyATYUYECWVYSPBS-UHFFFAOYSA-N
InChiInChI=1S/C20H15BrN4O/c1-13-15(12-22-25(13)18-9-5-3-7-16(18)21)20(26)24-19-11-10-14-6-2-4-8-17(14)23-19/h2-12H,1H3,(H,23,24,26)
Cas号2131223-85-1
相关CAS号

订购信息

包装价格库存纯度备货期
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外观性状固体粉末
纯度98% Min.
存储短期(几天到几周)为0-4摄氏度,长期(几个月)为-20摄氏度
可溶性溶于DMSO
处理方式
运输条件作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周.
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1. Yang W, Li Y, Ai Y, Obianom ON, Guo D, Yang H, Sakamuru S, Xia M, Shu Y, Xue F. Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation. J Med Chem. 2019 Dec 10. doi: 10.1021/acs.jmedchem.9b01252. [Epub ahead of print] PubMed PMID: 31769984.

化学结构

20494 - YW2065 | CAS 2131223-85-1

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