Z-IETD-FMK
编号: 16122771
Cas号: 210344-98-2
纯度: 98%
Z-IETD-FMK is a specific Caspase-8 inhibitor.Z-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli. [1] Z-IETD-FMK (50 M) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. [2] Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production, and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures.
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化学信息
| 名称 | Z-IETD-FMK |
|---|---|
| Iupac 化学名称 | Z-IETD-FMK |
| 同义词 | Caspase-8 Inhibitor |
| 英文同义词 | Caspase-8 Inhibitor |
| 分子式 | C30H43FN4O11 |
| 分子量 | 654.68 |
| Smile | CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)CF)NC(=O)OCc1ccccc1 |
| InChiKey | CTXDBLYOEUERAT-VUVYEONESA-N |
| InChi | InChI=1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1 |
| Cas号 | 210344-98-2 |
| MDL | MFCD01861686 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
