ZK-756326 is a potent, selective and non-peptide CCR8 chemokine receptor agonist. ZK 756326 inhibited the binding of the CCR8 ligand I-309 (CCL1), with an IC(50) value of 1.8 muM. ZK 756326 was a full agonist of CCR8, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1.
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化学信息
名称 | ZK-756326 dihydrochloride |
Iupac 化学名称 | ZK-756326 dihydrochloride |
同义词 | ZK-756326; ZK 756326; ZK756326; ZK-756326 dihydrochloride |
英文同义词 | ZK-756326; ZK 756326; ZK756326; ZK-756326 dihydrochloride |
分子式 | C21H30Cl2N2O3 |
分子量 | 429.382 |
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InChi | |
Cas号 | 1780259-94-0 |
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外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
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