ZLN024 hydrochloride
编号: 611814
Cas号: 1883548-91-1
纯度: 98%
ZLN024 Hcl is a novel AMPK allosteric activator; activated 111 and 211 by around 2C2.5 fold with an EC50 of about 1C2 uM.
ZLN024 activated AMPK in L6 myotubes and stimulated glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. ZLN024 also activated AMPK in primary hepatocytes, decreased fatty acid synthesis and glucose output. Treatment of db/db mice with 15 mg/kg/day ZLN024 improved glucose tolerance; liver tissue weight, triacylglycerol and the total cholesterol content were decreased. The hepatic transcriptional level of G6Pase, FAS and mtGPAT were reduced.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | ZLN024 hydrochloride |
|---|---|
| Iupac 化学名称 | ZLN024 hydrochloride |
| 同义词 | ZLN-024 hydrochloride |
| 英文同义词 | ZLN-024 hydrochloride |
| 分子式 | C13H14BrClN2OS |
| 分子量 | 361.69 |
| Smile | C[Si](C)(C)CSCCl |
| InChiKey | IKWIERSJEROYFH-UHFFFAOYSA-N |
| InChi | InChI=1S/C5H13ClSSi/c1-8(2,3)5-7-4-6/h4-5H2,1-3H3 |
| Cas号 | 1883548-91-1 |
| MDL | MFCD17013410 |
| 相关CAS号 |
订购信息
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