ZSTK474
编号: 160926006
Cas号: 475110-96-4
纯度: 98% by HPLC
Combination treatment using X-rays then ZSTK474 given orally for 8 days, starting 24h post-irradiation, significantly enhanced cell growth inhibition. The combined effect was also observed for clonogenic survival with continuous ZSTK474 treatment. Western blot analysis showed enhanced phosphorylation of Akt and GSK-3 by X-irradiation, whereas phosphorylation was inhibited by ZSTK474 treatment alone. Treatment with ZSTK474 after X-irradiation also inhibited phosphorylation, and remarkably inhibited xenograft tumor growth.
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化学信息
| 名称 | ZSTK474 |
|---|---|
| Iupac 化学名称 | 4,4'-(6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine |
| 同义词 | ZSTK474; ZSTK-474; ZSTK 474 |
| 英文同义词 | ZSTK474; ZSTK-474; ZSTK 474 |
| 分子式 | C19H21F2N7O2 |
| 分子量 | 417.41255 |
| Smile | FC(C1=NC2=C(N1C1=NC(=NC(=N1)N1CCOCC1)N1CCOCC1)C=CC=C2)F |
| InChiKey | HGVNLRPZOWWDKD-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2 |
| Cas号 | 475110-96-4 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
