b-AP15 is a specific inhibitor of the deubiquitinating enzymes Uch37 and Usp14 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome. Treating cells with b-AP15 causes the accumulation of polyubiquitinated proteins, inhibition of proteasomal degradation, upregulation of apoptotic markers and cell death.
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化学信息
名称 | b-AP15 |
Iupac 化学名称 | (3E,5E)-1-acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one |
同义词 | NSC687852; NSC 687852; NSC-687852 |
英文同义词 | NSC687852; NSC 687852; NSC-687852 |
分子式 | C22H17N3O6 |
分子量 | 419.39 |
Smile | C(C=C)(=O)N1C\C(\C(/C(/C1)=C/C1=CC=C(C=C1)[N+](=O)[O-])=O)=C/C1=CC=C(C=C1)[N+](=O)[O-] |
InChiKey | GFARQYQBWJLZMW-JYFOCSDGSA-N |
InChi | InChI=1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+ |
Cas号 | 1009817-63-3 |
相关CAS号 | |
外观性状 | Yellow solid powder |
纯度 | 97% |
存储 | -20 ºC for 3 years |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |