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1Z105

编号: 20567
Cas号: 1438280-73-9
纯度: 98% Min.

1Z105 is a TLR4/MD2 ligand, significantly reducing the IL-6 secretion by subsequent challenge with LPS.

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化学信息

名称1Z105
Iupac 化学名称N-Cyclohexyl-2-((5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetamide
同义词 1Z105, 1Z-105, 1Z 105
英文同义词 1Z105, 1Z-105, 1Z 105
分子式C25H26N4O2S
分子量446.56
SmileO=C(NC1CCCCC1)CSC2=NC3=C(C(N2C4=CC=CC=C4)=O)N(C)C5=C3C=CC=C5
InChiKeyXIGDXFCDNWREER-UHFFFAOYSA-N
InChiInChI=1S/C25H26N4O2S/c1-28-20-15-9-8-14-19(20)22-23(28)24(31)29(18-12-6-3-7-13-18)25(27-22)32-16-21(30)26-17-10-4-2-5-11-17/h3,6-9,12-15,17H,2,4-5,10-11,16H2,1H3,(H,26,30)
Cas号1438280-73-9
相关CAS号

订购信息

包装价格库存纯度备货期
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外观性状固体粉末
纯度98% Min.
存储短期(几天到几周)为0-4摄氏度,长期(几个月)为-20摄氏度
可溶性溶于DMSO
处理方式
运输条件作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周.
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Rajaiah R, Perkins DJ, Ireland DD, Vogel SN. CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8391-6. doi: 10.1073/pnas.1424980112. Epub 2015 Jun 23. PubMed PMID: 26106158; PubMed Central PMCID: PMC4500272.

2: Goff PH, Hayashi T, Martínez-Gil L, Corr M, Crain B, Yao S, Cottam HB, Chan M, Ramos I, Eggink D, Heshmati M, Krammer F, Messer K, Pu M, Fernandez-Sesma A, Palese P, Carson DA. Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses. J Virol. 2015 Mar;89(6):3221-35. doi: 10.1128/JVI.03337-14. Epub 2015 Jan 7. PubMed PMID: 25568203; PubMed Central PMCID: PMC4337541.

3: Hayashi T, Crain B, Yao S, Caneda CD, Cottam HB, Chan M, Corr M, Carson DA. Novel synthetic toll-like receptor 4/MD2 ligands attenuate sterile inflammation. J Pharmacol Exp Ther. 2014 Aug;350(2):330-40. doi: 10.1124/jpet.114.214312. Epub 2014 Jun 3. PubMed PMID: 24893985; PubMed Central PMCID: PMC4109491.

化学结构

20567 - 1Z105 | CAS 1438280-73-9

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