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定制合成

Sun-shinechem offers a full range of services in custom organic synthesis, including custom synthesis of building blocks, APIs, metabolites, reference compounds, process chemistry and libray synthesis. Sun-shine Chemicals' scientific and technology team has rich experience in complex organic synthesis, process design and manufacturing. So we can provide custom synthesis and contract research of almost any organic compound. General process is as follows:

  • Literature & database study
  • Design of synthetic routes
  • Investigation of availability for all key raw materials
  • Laboratory synthesis of new products
  • Full analysis conducted
  • Analysis of new synthetic route performed
  • Lead optimization
  • Technology transfer to manufacturing site
  • Search for potential contractors for commercial production
  • Scale-up

1. Custom Synthesis

The customer provides literature methods or their own synthesis route in which all details (reaction times, solvents, temperatures, analytical data, purification methods, yields, etc.) are included. The more information provided, the shorter the timelines and the lower the price. Our team will analysis synthesis and determine whether to pursue the project. If so, we will provide an estimate of cost and delivery time.

Case: Synthesis of Isoquinolin-7-amine

We find some synthetic methods of the compound by literature & database study, and at end we select the route as follows to synthesize the compound, and desired product was also obtained.

Reference:

a. IsoQuinolines. Part III. The nitration of 3 : 4-dihydro- and 1 : 2 : 3 : 4-tetrahydro-isoquinolines, A. McCoubrey and David W. Mathieson, J. Chem. Soc., 1951, 2851-2853, DOI: 10.1039/JR9510002851, Paper 

b. Studies of the amino-isoquinolines,-cinnolines, and -quinazolines, A. R. Osborn, K. Schofield and L. N. Short, J. Chem. Soc., 1956, 4191-4206, DOI: 10.1039/JR9560004191, Paper

2. Contract Research

When synthetic information is limited or unavailable, contract research will be carried out. Our synthesis design expertise will conduct literature research of target compounds and determine best route of synthesis.