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ALZ-801

编号: 20450
Cas号: 1034190-08-3
纯度: 98% Min.

ALZ-801 is an oral, small-molecule inhibitor of beta amyloid (Aβ) oligomer formation for Alzheimer's disease (AD). ALZ-801 is a prodrug of tramiprosate with improved pharmacokinetic properties and gastrointestinal tolerability.

仅供研究使用。 我们不向患者出售。

化学信息

名称ALZ-801
Iupac 化学名称(S)-3-(2-Amino-3-methylbutanamido)propane-1-sulfonic acid
同义词ALZ-801; ALZ801; ALZ 801; BLU8499; BLU 8499; BLU-8499; NRM8499; NRM 8499; NRM-8499
英文同义词ALZ-801; ALZ801; ALZ 801; BLU8499; BLU 8499; BLU-8499; NRM8499; NRM 8499; NRM-8499
分子式C8H18N2O4S
分子量238.30
SmileO=S(CCCNC([C@@H](N)C(C)C)=O)(O)=O
InChiKeyNRZRFNYKMSAZBI-ZETCQYMHSA-N
InChiInChI=1S/C8H18N2O4S/c1-6(2)7(9)8(11)10-4-3-5-15(12,13)14/h6-7H,3-5,9H2,1-2H3,(H,10,11)(H,12,13,14)/t7-/m0/s1
Cas号1034190-08-3
相关CAS号

订购信息

包装价格库存纯度备货期
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外观性状固体粉末
纯度98% Min.
存储短期(几天到几周)为0-4摄氏度,长期(几个月)为-20摄氏度
可溶性溶于DMSO
处理方式
运输条件作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周.
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Hey JA, Kocis P, Hort J, Abushakra S, Power A, Vyhnálek M, Yu JY, Tolar M. Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain. CNS Drugs. 2018 Aug 3. doi: 10.1007/s40263-018-0554-0. [Epub ahead of print] PubMed PMID: 30076539.

2: Abushakra S, Porsteinsson A, Scheltens P, Sadowsky C, Vellas B, Cummings J, Gauthier S, Hey JA, Power A, Wang P, Shen L, Tolar M. Clinical Effects of Tramiprosate in APOE4/4 Homozygous Patients with Mild Alzheimer's Disease Suggest Disease Modification Potential. J Prev Alzheimers Dis. 2017;4(3):149-156. doi: 10.14283/jpad.2017.26. PubMed PMID: 29182706.

3: Hey JA, Yu JY, Versavel M, Abushakra S, Kocis P, Power A, Kaplan PL, Amedio J, Tolar M. Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer's Disease. Clin Pharmacokinet. 2018 Mar;57(3):315-333. doi: 10.1007/s40262-017-0608-3. PubMed PMID: 29063518; PubMed Central PMCID: PMC5814546.

4: Kocis P, Tolar M, Yu J, Sinko W, Ray S, Blennow K, Fillit H, Hey JA. Elucidating the Aβ42 Anti-Aggregation Mechanism of Action of Tramiprosate in Alzheimer's Disease: Integrating Molecular Analytical Methods, Pharmacokinetic and Clinical Data. CNS Drugs. 2017 Jun;31(6):495-509. doi: 10.1007/s40263-017-0434-z. PubMed PMID: 28435985; PubMed Central PMCID: PMC5488121.


化学结构

20450 - ALZ-801 | CAS 1034190-08-3

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