BI-1467335 HCl
BI-1467335, also known as PXS-4728A, is a SSAO/VAP inhibitor potentially for the treatment of non-alcoholic steatohepatitis. VAP-1/SSAO contributes to the migration of neutrophils during acute lung inflammation, pulmonary infection and airway hyperractivity. Selective VAP-1/SSAO inhibition by PXS-4728A diminished leukocyte rolling and adherence induced by CXCL1/KC. Inhibition of VAP-1/SSAO also dampened the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis; whilst still allowing for normal neutrophil defense function, resulting in increased survival.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | BI-1467335 HCl |
|---|---|
| Iupac 化学名称 | (E)-4-((2-(aminomethyl)-3-fluoroallyl)oxy)-N-(tert-butyl)benzamide hydrochloride |
| 同义词 | PXS-4728A; PXS4728A; PXS 4728A; BI-1467335; BI 1467335; BI1467335; BI-1467335 HCl; BI-1467335 hydrochloride |
| 英文同义词 | PXS-4728A; PXS4728A; PXS 4728A; BI-1467335; BI 1467335; BI1467335; BI-1467335 HCl; BI-1467335 hydrochloride |
| 分子式 | C15H22ClFN2O2 |
| 分子量 | 316.80 |
| Smile | O=C(NC(C)(C)C)C1=CC=C(OC/C(CN)=C/F)C=C1.[H]Cl |
| InChiKey | AEMZEDNMNLIDSL-YGCVIUNWSA-N |
| InChi | InChI=1S/C15H21FN2O2.ClH/c1-15(2,3)18-14(19)12-4-6-13(7-5-12)20-10-11(8-16)9-17;/h4-8H,9-10,17H2,1-3H3,(H,18,19);1H/b11-8+; |
| Cas号 | 1478364-68-9 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周. |
| 海关编码 |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Schilter HC, Collison A, Russo RC, Foot JS, Yow TT, Vieira AT, Tavares LD, Mattes J, Teixeira MM, Jarolimek W. Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration. Respir Res. 2015 Mar 20;16:42. doi: 10.1186/s12931-015-0200-z. PubMed PMID: 25889951; PubMed Central PMCID: PMC4389443.
2: Jarnicki AG, Schilter H, Liu G, Wheeldon K, Essilfie AT, Foot JS, Yow TT, Jarolimek W, Hansbro PM. The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model. Br J Pharmacol. 2016 Nov;173(22):3161-3175. doi: 10.1111/bph.13573. PubMed PMID: 27495192; PubMed Central PMCID: PMC5071557.
3: Katagiri D, Hamasaki Y, Doi K, Negishi K, Sugaya T, Nangaku M, Noiri E. Interstitial renal fibrosis due to multiple cisplatin treatments is ameliorated by semicarbazide-sensitive amine oxidase inhibition. Kidney Int. 2016 Feb;89(2):374-85. PubMed PMID: 26535996.
