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CO-1686(Rociletinib) 编号 : 60701

化学信息

产品英文名称CO-1686(Rociletinib)
Iupac 化学名称N-(3-((2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluorom ethyl)pyrimidin-4-yl)amino)phenyl)acrylamide 
同义词AVL-301;CNX-4;CO1686;Rociletinib;CO-1686;CO 1686 
英文同义词AVL-301;CNX-4;CO1686;Rociletinib;CO-1686;CO 1686 
分子式C27H28F3N7O3 
分子量555.55 
SmileC(C)(=O)N1CCN(CC1)C1=CC(=C(C=C1)NC1=NC=C(C(=N1)NC=1C=C(C=CC1)NC(C=C)=O)C(F)(F)F)OC
InChiKeyHUFOZJXAKZVRNJ-UHFFFAOYSA-N
InChiInChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)
Cas1374640-70-6

技术数据

外观off-white solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature 
质量控制 HNMR

产品详情

CO-1686(Rociletinib) is an irreversible inhibitor of epidermal growth factor receptor (EGFR).CO-1686(Rociletinib) was used for  EGFR-Mutated NonCSmall-Cell Lung Cancer.Rociletinib was active in patients with EGFR-mutated NSCLC associated with the T790M resistance mutation. (Funded by Clovis Oncology; ClinicalTrials.gov number, NCT01526928.)

 

结构

60701 - CO-1686(Rociletinib) | CAS 1374640-70-6

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