GDC-0214
iJak-381 is a highly potent, selective, and inhalable Janus kinase-1 (JAK-1) inhibitor which shows about 950 times higher concentration in the lungs than in plasma after inhalation in mice. iJak-381 suppresses the signal transducer and activator of transcription 6 activation by IL-13.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | GDC-0214 |
|---|---|
| Iupac 化学名称 | Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(2-cyanoethyl)methylamino]-1-piperidinyl]-2-oxoethyl]-1H-pyrazol-4-yl]- |
| 同义词 | GDC-0214，iJak-381 |
| 英文同义词 | GDC-0214，iJak-381 |
| 分子式 | C28H28ClF2N9O3 |
| 分子量 | 612.03 |
| Smile | O=C(C4=C3N=CC=CN3N=C4)NC1=CN(CC(N5CCC(N(CCC#N)C)CC5)=O)N=C1C2=CC(Cl)=CC=C2OC(F)F |
| InChiKey | ITNFPSJJBYFVEA-UHFFFAOYSA-N |
| InChi | InChI=1S/C28H28ClF2N9O3/c1-37(10-2-8-32)19-6-12-38(13-7-19)24(41)17-39-16-22(35-27(42)21-15-34-40-11-3-9-33-26(21)40)25(36-39)20-14-18(29)4-5-23(20)43-28(30)31/h3-5,9,11,14-16,19,28H,2,6-7,10,12-13,17H2,1H3,(H,35,42) |
| Cas号 | 1831144-46-7 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周. |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Dengler HS, Wu X, Peng I, Rinderknecht CH, Kwon Y, Suto E, Kohli PB, Liimatta M, Barrett K, Lloyd J, Cain G, Briggs M, Addo S, Salmon G, Ubhayakar S, Deshmukh G, Shahidi-Latham SK, Quiason-Huynh CM, Jackman J, Liu J, Ray NC, Goodacre SC, Johnson A, McKenzie BS, Lee WP, Zak M, Kenny JR, Ghilardi N. Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma. Sci Transl Med. 2018 Nov 21;10(468). pii: eaao2151. doi: 10.1126/scitranslmed.aao2151. PubMed PMID: 30463918.
