GNF-PF-3777
GNF-PF-3777 is a derivative of tryptanthrin.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | GNF-PF-3777 |
|---|---|
| Iupac 化学名称 | 8-nitro-indolo[2,1-b]quinazoline-6,12-dione |
| 同义词 | 8-Nitrotryptanthrin, GNF-PF-3777 |
| 英文同义词 | 8-Nitrotryptanthrin, GNF-PF-3777 |
| 分子式 | C15H7N3O4 |
| 分子量 | 293.24 |
| Smile | O=C1C2=CC=CC=C2N=C3N1C(C=CC([N+]([O-])=O)=C4)=C4C3=O |
| InChiKey | UFMQJYHLIUACCG-UHFFFAOYSA-N |
| InChi | InChI=1S/C15H7N3O4/c19-13-10-7-8(18(21)22)5-6-12(10)17-14(13)16-11-4-2-1-3-9(11)15(17)20/h1-7H |
| Cas号 | 77603-42-0 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 可溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周 |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1. Yang, S., Li, X., Hu, F., et al. Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. J. Med. Chem. 56(21), 8321-8331 (2013).
2. Sharma, V.M., Prasanna, P., Seshu, K.V., et al. Novel indolo[2,1-b]quinazoline analogues as cytostatic agents: Synthesis, biological evaluation and structure-activity relationship. Bioorg. Med. Chem. Lett. 12(17), 2303-2307 (2002).
3. Hwang, J.-M., Oh, T., Kaneko, T., et al. Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents. J. Nat. Prod. 76(3), 354-367 (2013).
4. Kawakami, J., Matsushima, N., Ogawa, O., et al. Antibacterial and antifungal activities of tryptanthrin derivatives. Trans. Mater. Res. Soc. Jpn. 36(4), 603-606 (2011).
5. Scovill, J., Blank, E., Konnick, M., et al. Antitrypanosomal activities of tryptanthrins. Antimicrob. Agents Chemother. 46(3), 882-883 (2002).
