KSQ-4279
编号: 20472
Cas号: 2446480-97-1
纯度: 98% Min.
KSQ-4279 is a USP1 and PARP inhibitor. KSQ-4279 showed anti-proliferative effects in a subset of cell lines, often characterized by the presence of homologous recombination deficiencies (HRD), including mutations in BRCA1/2. The combination of KSQ-4279 with olaparib was able to induce strong and durable regressions across a number of ovarian and TNBC PDX models.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | KSQ-4279 |
|---|---|
| Iupac 化学名称 | 1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]- |
| 同义词 | KSQ-4279; KSQ 4279; KSQ4279; |
| 英文同义词 | KSQ-4279; KSQ 4279; KSQ4279; |
| 分子式 | C27H25F3N8O |
| 分子量 | 534.54 |
| Smile | FC(C1=CN(C(C)C)C(C2=CC=C(CN3N=CC4=CN=C(C5=C(OC)N=CN=C5C6CC6)N=C43)C=C2)=N1)(F)F |
| InChiKey | KCBWAFJCKVKYHO-UHFFFAOYSA-N |
| InChi | InChI=1S/C27H25F3N8O/c1-15(2)37-13-20(27(28,29)30)35-24(37)18-6-4-16(5-7-18)12-38-25-19(11-34-38)10-31-23(36-25)21-22(17-8-9-17)32-14-33-26(21)39-3/h4-7,10-11,13-15,17H,8-9,12H2,1-3H3 |
| Cas号 | 2446480-97-1 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
