LSN2463359
LSN2463359 is a novel positive allosteric modulators of the mGlu₅ receptor.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | LSN2463359 |
|---|---|
| Iupac 化学名称 | N-(propan-2-yl)-5-[2-(pyridin-4-yl)ethynyl]pyridine-2-carboxamide |
| 同义词 | LSN2463359; LSN-2463359; LSN 2463359. |
| 英文同义词 | LSN2463359; LSN-2463359; LSN 2463359. |
| 分子式 | C16H15N3O |
| 分子量 | 265.31 |
| Smile | O=C(C1=NC=C(C#CC2=CC=NC=C2)C=C1)NC(C)C |
| InChiKey | STAFRSGTRKNXHF-UHFFFAOYSA-N |
| InChi | InChI=1S/C16H15N3O/c1-12(2)19-16(20)15-6-5-14(11-18-15)4-3-13-7-9-17-10-8-13/h5-12H,1-2H3,(H,19,20) |
| Cas号 | 1401031-52-4 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 纯度 | 98% Min. |
|---|---|
| 处理方式 | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Gilmour G, Broad LM, Wafford KA, Britton T, Colvin EM, Fivush A, Gastambide F, Getman B, Heinz BA, McCarthy AP, Prieto L, Shanks E, Smith JW, Taboada L, Edgar DM, Tricklebank MD. In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 2013 Jan;64:224-39. doi: 10.1016/j.neuropharm.2012.07.030. PubMed PMID: 22884720.
2: Gastambide F, Gilmour G, Robbins TW, Tricklebank MD. The mGlu₅ positive allosteric modulator LSN2463359 differentially modulates motor, instrumental and cognitive effects of NMDA receptor antagonists in the rat. Neuropharmacology. 2013 Jan;64:240-7. doi: 10.1016/j.neuropharm.2012.07.039. PubMed PMID: 22884612.
3: Gastambide F, Cotel MC, Gilmour G, O'Neill MJ, Robbins TW, Tricklebank MD. Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator. Neuropsychopharmacology. 2012 Mar;37(4):1057-66. doi: 10.1038/npp.2011.298. PubMed PMID: 22129780; PubMed Central PMCID: PMC3280638.
