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Inhibitors&Agonists
PI3K/Akt/mTOR
Epigenetics
Protein Tyrosine Kinase
Angiogenesis
Apoptosis
Autophagy
JAK/STAT
MAPK
Cytoskeletal Signaling
Cell Cycle
TGF-beta/Smad
DNA Damage
Stem Cells & Wnt
Ubiquitin
Neuronal Signaling
NF-κB
GPCR & G Protein
Metabolism
Anti-infection
Proteases
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Bromides
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Indoles and Oxindoles
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+86-17702719238
sales@sun-shinechem.com
Home
Inhibitors&Agonists
PI3K/Akt/mTOR
Epigenetics
Protein Tyrosine Kinase
Angiogenesis
Apoptosis
Autophagy
JAK/STAT
MAPK
Cytoskeletal Signaling
Cell Cycle
TGF-beta/Smad
DNA Damage
Stem Cells & Wnt
Ubiquitin
Neuronal Signaling
NF-κB
GPCR & G Protein
Metabolism
Anti-infection
Proteases
Immunology & Inflammation
Vitamin D Related
Membrane Transporter/Ion Channel
others
PROTAC
Building Blocks
Aldehydes
Amines
Amino Acids
Anilines
Boronic Acids
Bromides
Carboxes
Catalysts
Chiral Compounds
Deuterated
Fluorides
Imidazoles
Indoles and Oxindoles
Iodos
Nitro Compounds
Oxazoles
Peg Linkers
Phenols
Piperidines
Pyridines
Pyrimidines
Quinolines
Sulfonamides
Thiazoles
Trifluoroborates
Other Azoles
Other Heterocycles
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Name Index P
P5091 (P005091)
(Catalog# : 16122795, Cas# :
882257-11-6
)
P5091(P005091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (
PYR-41
(Catalog# : 16122793, Cas# :
418805-02-4
)
PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with
PRI-724
(Catalog# : 16122785, Cas# :
847591-62-2
)
PRI-724 is a potent, specific inhibitor of the canonical Wnt signaling pathway in can
PLX7904
(Catalog# : 16122777, Cas# :
1393465-84-3
)
PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor.
Pamapimod (R-1503, Ro4402257)
(Catalog# : 16122774, Cas# :
449811-01-2
)
Pamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activate
PRIMA-1
(Catalog# : 16122770, Cas# :
5608-24-2
)
PRIMA-1 is a mutant p53 reactivator. It induces apoptosis and inhibits growth of huma
Picolinamide
(Catalog# : 16122714, Cas# :
1452-77-3
)
Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuc
PD0166285
(Catalog# : 16122710, Cas# :
185039-89-8
)
PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentratio
Peficitinib (ASP015K, JNJ-54781532)
(Catalog# : 16122707, Cas# :
944118-01-8
)
Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.
PF-543 Citrate
(Catalog# : 6111525, Cas# :
1415562-83-2
)
PF-543 Citrate is a novel cell-permeant inhibitor of SphK1 with a K(i) of 3.6 nM, PF-
Pasireotide
(Catalog# : 61115, Cas# :
396091-73-9
)
Pasireotide(SOM 230) is a stable cyclohexapeptide somatostatin mimic that exhibits un
PFI-3
(Catalog# : 6111020, Cas# :
1819363-80-8
)
PFI-3
PF-2771
(Catalog# : 611943)
PF-2771 is a potent, selective CENP-E inhibitor, PF-2771 inhibits CENP-E motor activi
PF-04929113 Mesylate
(Catalog# : 611939, Cas# :
1173111-67-5
)
PF-04929113 Mesylate is a potent and selective Hsp90 inhibitor with an IC50 of median
PI4KIIIbeta-IN-9
(Catalog# : 611908, Cas# :
1429624-84-9
)
PI4KIII-IN-9 is a potent PI4KIII inhibitor (IC50 of 7 nM) and is >140-fold selecti
PI4KIIIbeta-IN-10
(Catalog# : 611907, Cas# :
1881233-39-1
)
PI4KIIIbeta-IN-10 is the most potent PI4KIII inhibitor currently reported, with very
PI3Kα inhibitor 1
(Catalog# : 611903, Cas# :
1235449-52-1
)
PI3Kα inhibitor 1 is a PI3Kα inhibitor extracted from patent US/20120088764A1, comp
PF-04979064
(Catalog# : 611902, Cas# :
1220699-06-8
)
PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50)
PQR620
(Catalog# : 611821, Cas# :
1927857-56-4
)
PRQ620 is a highly potent and selective mTORC1/2 inhibitor, shows anti-tumor effects
PP121
(Catalog# : 161009011, Cas# :
1092788-83-4
)
PP121 blocks the proliferation of tumor cells by direct inhibition of oncogenic tyros
PF-4989216
(Catalog# : 161009002, Cas# :
1276553-09-3
)
PF-4989216 inhibits the phosphorylation of PI3K downstream molecules and subsequently
PIK-294
(Catalog# : 160926013, Cas# :
900185-02-6
)
PIK-294 is a highly selective inihibitor of the phosphoinositide 3-kinase (PI3K) p110
PIK-90
(Catalog# : 160926010, Cas# :
677338-12-4
)
PIK-90 is a potent PI3K inhibitor with potential anticancer activity.
PIK-93
(Catalog# : 160926009, Cas# :
593960-11-3
)
PIK-93 is a potent PI3K inhibitor. PIK93 selectively inhibits the type III PI 4-kinas
PI-103
(Catalog# : 160926002, Cas# :
371935-74-9
)
It inhibits ATR and ATM only at much higher concentrations (IC50= 850 and 920 nM, res
PNU-159682
(Catalog# : 16071409, Cas# :
202350-68-3
)
PNU-159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsom
Pevonedistat
(Catalog# : 16071408, Cas# :
905579-51-3
)
Pevonedistat, also known as MLN-4924 and TAK-924, is a small molecule inhibitor of Ne
PRX-08066
(Catalog# : 16071114, Cas# :
866206-54-4
)
PRX-08066 is a a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotal
PS 48
(Catalog# : 16071111, Cas# :
1180676-32-7
)
PS 48 has been shown to be a PKB Kinase (phosphoinositide-dependent protein kinase-1,
Panulisib
(Catalog# : 16071030, Cas# :
1356033-60-7
)
Panulisib, also known as AK151761, is a potent and selective imidazoquinoline based P
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Products Catalog
Signaling Pathway
-- PI3K/Akt/mTOR
----
PI3K
----
Akt
----
GSK-3
----
S6 Kinase
----
AMPK
----
DNA-PK
----
MELK
----
PIKfyve
----
PI4K
----
PTEN
----
mTOR
----
ATM
----
PDK-1
----
ATR
-- Epigenetics
----
PARP
----
JAK
----
Pim
----
PKC
----
PKD
----
Sirtuin
----
Histone Demethylase
----
Histone Acetyltransferase
----
HDAC
----
HIF-PH
----
Aurora Kinase
----
Histone Methyltransferase
----
METTL3
----
Epigenetic Reader Domain
-- Protein Tyrosine Kinase
----
VEGFR
----
EGFR
----
PDGFR
----
IGF-1R
----
FLT3
----
FGFR
----
c-Kit
----
Src
----
ALK
----
Ephrin receptor
----
BTK
----
Trk receptor
----
c-Met/HGFR
----
Syk (Spleen tyrosine kinase)
----
TAM Receptor
----
ULK1
----
CSF-1R
----
TYK2
----
ROS Kinase
-- Angiogenesis
----
VEGFR
----
JAK
----
EGFR
----
PDGFR
----
FLT3
----
FGFR
----
Bcr-Abl
----
Src
----
ALK
----
Syk
----
FAK
----
BTK
----
HIF
-- Apoptosis
----
PD-1
----
PD-L1
----
Bcl-2
----
Caspase
----
TNF-alpha
----
Survivin
----
IAP
----
PERK
----
p53
----
Mdm2
----
E1/E2/E3 Enzyme
-- Autophagy
----
LRRK2
----
CXCR
----
Autophagy
-- JAK/STAT
----
JAK
----
STAT
----
Pim
----
EGFR
-- MAPK
----
MEK
----
Raf
----
p38 MAPK
----
ERK
----
MNK
----
Mixed Lineage Kinase
----
JNK
----
MAP4K
-- Cytoskeletal Signaling
----
Akt
----
Bcr-Abl
----
PKC
----
FAK
----
HSP
----
Kinesin
----
Integrin
----
Dynamin
----
Wnt
----
β-catenin
-- Cell Cycle
----
CDK
----
PD-1
----
PD-L1
----
Chk
----
ROCK
----
PLK
----
APC
----
Wee1
----
DYRK
----
c-Myc
----
Aurora Kinase
----
ROCK inhibitor
-- TGF-beta/Smad
----
Bcr-Abl
----
PKC
----
ROCK
----
TGF-beta/Smad
-- DNA Damage
----
PARP
----
DNA/RNA Synthesis
----
Sirtuin
----
Topoisomerase
----
DNA-PK
----
Telomerase
----
RAD51
----
HDAC
----
ATM
----
DNA alkylator
----
Mps1
-- Stem Cells & Wnt
----
GSK-3
----
JAK
----
STAT
----
ROCK
----
TGF-beta/Smad
----
Wnt
----
γ-secretase
----
β-catenin
----
smo
-- Ubiquitin
----
Proteasome
----
p97
----
Deubiquitinase
-- Neuronal Signaling
----
COX
----
Histamine Receptor
----
Dopamine Receptor
----
Opioid Receptor
----
GABA Receptor
----
OX Receptor
----
Amyloid-β
----
5-HT Receptor
----
γ-secretase
----
Adrenergic Receptor
----
NMDA Receptor
----
GlyT1
----
Beta-secretase
----
α-Synuclein
----
Tau Protein
----
Cannabinoid Receptor
----
Transthyretin (TTR)
-- NF-κB
----
NF-κB
----
HDAC
----
IKK
-- GPCR & G Protein
----
Histamine Receptor
----
Dopamine Receptor
----
Opioid Receptor
----
Endothelin Receptor
----
SGLT
----
OX Receptor
----
CaSR
----
CXCR
----
Vasopressin Receptor
----
Glucagon Receptor
----
Prostaglandin Receptor
----
5-HT Receptor
----
Adrenergic Receptor
----
Cannabinoid Receptor
----
Sphingosine 1 Phosphate Receptor
----
PKA
----
Adenosine Receptor
----
GnRH
----
LPL Receptor
----
Sigma Receptor
----
Ras
----
mAChR
----
Cholecystokinin Receptor
----
Melanocortin Receptor
----
RXFP Receptor
-- Metabolism
----
PPAR
----
P450
----
HSP
----
PDE
----
Factor Xa
----
Phospholipase
----
FAAH
----
CETP
----
Lipoxygenase
----
HMG-CoA Reductase
----
Fatty Acid Synthase
----
FXR
----
NAMPT
----
TDO
----
Carbonic Anhydrase
----
Monoamine Oxidase
----
IDO
----
MAGL
----
Epoxide Hydrolase
----
LXR
----
Myeloperoxidase (MPO)
----
RAR/RXR
----
Acyltransferase
----
UGT
----
MMP
----
ATP Citrate Lyase
-- Anti-infection
----
CMV
----
Filovirus
----
HBV
----
HCV
----
HIV
----
HSV
----
Influenza Virus
----
RSV
----
SARS-CoV
----
Antibacterial
----
Antifungal
----
Parasite
-- Proteases
----
Proteasome
----
Caspase
----
HIV Protease
----
MMP
----
γ-secretase
----
DPP4
----
Mitochondrial Metabolism
----
Isocitrate Dehydrogenase (IDH)
----
FPTase
----
Acetyl-CoA Carboxylase
----
Glutaminase
-- Immunology & Inflammation
----
PD-1
----
PD-L1
----
COX
----
CCR
----
Histamine Receptor
----
TLR
----
CXCR
----
MALT
----
TDO
----
NOS
----
NADPH-oxidase
----
IDO
----
Thrombopoietin Receptor(TPO)
----
NLR inhibitor
----
Interleukin Related
----
CD73
----
Complement System
----
Aryl Hydrocarbon Receptor
-- Vitamin D Related
----
VD/VDR
-- Membrane Transporter/Ion Channel
----
BCRP
----
CFTR
----
EAAT2
----
GABA Receptor
----
HCN Channel
----
Monoamine Transporter
----
Na+/Ca2+ Exchanger
----
Na+/K+ ATPase
----
nAChR
----
Calcium Channel
----
Chloride Channel
----
CRAC Channel
----
GlyT1
----
iGluR
----
P2X Receptor
----
P-glycoprotein
----
Amino acid transporter
----
Monocarboxylate Transporter
----
Potassium Channel
-- others
----
PKK
----
Others modulator
----
Estrogen Receptor/ERR
----
ChoKα
-- PROTAC
----
Molecular Glues
Inhibitors & Agonists
Intermediates
Building Blocks
--
Aldehydes
--
Amines
--
Amino Acids
--
Anilines
--
Boronic Acids
--
Bromides
--
Carboxes
--
Catalysts
--
Chiral Compounds
--
Deuterated
--
Fluorides
--
Imidazoles
--
Indoles and Oxindoles
--
Iodos
--
Nitro Compounds
--
Oxazoles
--
Peg Linkers
--
Phenols
--
Piperidines
--
Pyridines
--
Pyrimidines
--
Quinolines
--
Sulfonamides
--
Thiazoles
--
Trifluoroborates
--
Other Azoles
--
Other Heterocycles
--
Other Building Blocks
--
On Sale
New Products
Natural Compounds
Latest Products
STX-478
(Catalog# : 20633, Cas# :
2883540-92-7
)
STX-478 is a second generation, mutant-selective, oral PI3Ka small molecule allosteri
Iclepertin (BI-425809)
(Catalog# : 24084, Cas# :
1421936-85-7
)
Iclepertin (BI-425809) is an oral, small-molecule inhibitor of GlyT-1for the treatmen
Bomedemstat
(Catalog# : 24001, Cas# :
1990504-34-1
)
Bomedemstat is anorally available, irreversible inhibitor of lysine-specific demethyl
PLX-4545
(Catalog# : 24111, Cas# :
2892065-45-9
)
PLX-4545 is an orally bioavailable molecular glue degrader of IKZF2 designed to desta
VVD-130037 ( BAY-3605349 )
(Catalog# : 24110, Cas# :
3034880-93-5
)
VVD-130037 (BAY-3605349) is an oral, small-molecule activator of KEAP1 (INrf2).
CBR-5884
(Catalog# : 24109, Cas# :
681159-27-3
)
CBR 5884 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor which was able to inhi
JHU-083
(Catalog# : 24108, Cas# :
1998725-11-3
)
JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents de
LXH-3-71
(Catalog# : 24107, Cas# :
2251753-65-6
)
LXH-3-71 isnovel "molecular glue"that induces the interaction between PHGDH
CC-92480 ( Mezigdomide )
(Catalog# : 20510, Cas# :
2259648-80-9
)
CC-92480 Is a Novel Cereblon E3 Ligase Modulator with Enhanced Tumoricidal and Immuno
Adrixetinib ( Q-702 )
(Catalog# : 20617, Cas# :
2394874-66-7
)
Adrixetinib is a tyrosine kinase inhibitor with potential use as an antineoplastic ag